I've used lots of Bacopa (Brahmi) which exerts neuroprotective [1], anticonvulsant, antipsychotic and memory-enhancing activities [2]. Preclinical results indicate that Bacopa monnieri extract administration has antidepressant and procognitive effects [3]. Centella asiatica - Gotu kola While proposed to be a "true adaptogen that promote harmony on the mind, body and spirit" [4] [5] . This contains pentacyclic triterpenes at 19.5-37.4 mg/g dry powder Asiatic acid [6] has antioxidant, anti-inflammatory, hepatoprotective, cardioprotective, neuroprotective, gastroprotective, and anticancer properties. It is promising for memory and cognition enhancement - used either alone or as an adjuvant in neuropsychiatric diseases as well as in learning and memory impairment. Along with a multitude of receptor and enzyme actions. asiatic acid supposedly modulates the benzodiazepine site on the GABAA receptor and exerts anxiolytic effects [7] It was found C. asiatica significantly increased GAD activity in vitro, increased whole brain GABA and human studies found reductions in acoustic startle - producing anxiolytic effects but no alteration in mood in high (12g) dose acute settings and "significant improvements in anxiety following 60 days of treatment on the HAM‐A scale, along with significant reductions in secondary measures of stress and depression" [8]. Another study claims the effect of negative modulation of different GABAA receptor subtypes, particularly on α5-containing GABAA receptors which may be beneficial for cognitive disorders and anxiety [9]. This is interesting as negative allosteric modulators of α5 subunit-containing GABAA receptors are reported to show rapid-acting antidepressant effects in rodents [10]. Antagonists are proposed to provide enhancement and remediation of cognitive performance with anxiolytic/antidepressant-like effects [11]. In contrary, positive modulation has been proposed in schizophrenia to address dopaminergic abnormalities. It is proposed to be a GABAB receptor agonist and have effects on AChE [12] One person suggests "If you think that ashwagandha is a potent anxiolytic, it's nothing compared to Gotu Kola... This herbal anxiolytic has comparable strength to pharma-grade drugs, which is impressive, and a little scary at the same time." That said, another person said "I took it for a month and didn't notice anything from it." another it "clears my mind and allows me to focus" It also has: - potent antioxidant and free radical scavenging properties. Augments activities/levels of both enzymatic and non-enzymatic antioxidants. - regulates pro-inflammatory cytokines and preventing the development and progression of immune-inflammatory disorders
0 Comments
Leave a Reply. |
Details
ArchivesCategories |