Lemon Balm - Melissa Officinalis I grow and use this quite a bit. I've recently been using it as a tea with Passiflora and Chamomile It is said to cheer the heart and lift the spirits, to balance feelings and emotions [1]. Lemon balm treatments were generally associated with improvements in mood and/or cognitive performance [2] Improvements in feelings include “calm”, “secure”, “at ease”, “satisfied”, “comfortable”, “self-confident”, “relaxed”, “content’, “steady” and “pleasant”. "Twenty healthy young participants received single doses of 600, 1000, and 1600 mg of encapsulated dried leaf, or a matching placebo, at 7-day intervals. Cognitive performance and mood were assessed before dose and at 1, 3, and 6 h after dose - data supported the cholinergic receptor-binding properties of M. officinalis and the fact that it acts on mood and cognition in a dose- and time-dependent manner [3] 60 drops/day of lemon balm extract exerted positive effects on cognition in Alzheimer’s Disease Essential oils obtained from Melissa officinalis leaf showed high acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. It is an efficient antioxidant and hypoglycaemic agent. Melissa inhibited binding of GABAA to receptor channel in the rat forebrain, but had no effect on or nicotinic acetylcholine receptors. They also found that Melissa elicited a significant dose-dependent reduction in both inhibitory and excitatory transmission. A 50:50 mixture of Melissa and Lavender essential oils inhibited [3H] flunitrazepam binding, whereas the individual oils had no significant effect.
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