Busy Mondays require morning therapeutic pep. Finally some deeper work covering methylxanthine synergies.
I'm shifting my diet this week. Moving led to a bit of a lapse in diet quality and a return to coffee. I want better brews than coffee... How to harness the power of methylxanthine synergies? Exploiting synergies seems to be useful as highlighted in this review Temporarily back into a bit of Matcha + Cacao which I found a nice blend to address multiple areas and more dense in polyphenols that things like guayusa. Targeting the motivational symptoms is challenging and most conventional treatments do not improve, and may worsen these areas which are critical in social functioning and treatment outcome [1]. The latest on theobromine: While it has a nonselective PDE inhibition effect greater than caffeine, oral theobromine inhibits mTOR signalling in vivo which is of relevance to multiple conditions [2] and elevates cerebral brain-derived neurotrophic factor and facilitates learning in animal models [3]. The more interesting properties of theobromine might lie in its synergistic effect with caffeine. That said, behavioural effects from theobromine such as an increase in alertness, energy and motivation, but also sleepiness in some subjects has been reported. "Research revealed that isolated doses of caffeine and theobromine exert differential – and possibly less beneficial – effects than methylxanthine preparations from plant sources that provide also a number of other phytochemicals. Five studies found a significant acute cognitive effect from cocoa, with improvements in visual information processing, spatial working memory, concentration and memory. Research suggests that tea catechins, mainly EGCG, elicit cognitive effects as well. EGCG administration has been associated with self-reported calmness and reduced stress in healthy subjects Several studies found that caffeine and L-theanine improve attentional performance but studies did not find any change in self-reported mood compared to caffeine. Some of the studies, even on more well-known combinations such as caffeine and L-theanine, failed at reproducing the same results as in other studies. L-theanine appears to be most beneficial in subjects that reported being more stressed and/or anxious during the study. EGCG may reduce the negative mood effects of caffeine in a similar manner to L-theanine. Theobromine may selectively enhance caffeine psychoactivity - increased “energetic arousal” as well. In terms of mood effects cocoa flavonoids may modify caffeine's psychoactive effects in a similar manner to L-theanine. Experiments found that combination of cocoa extract and caffeine attenuated the anxiety-provoking effects of caffeine alone Evidence for an improvement of executive function 90–150 min after the administration of cocoa flavanols. Caffeinated cocoa (70 mg caffeine, 179 mg theobromine, 499 mg flavanols) caused lower omission errors and improved accuracy in healthy subjects compared to cocoa alone (21 mg caffeine, 179 mg theobromine, 499 mg flavanols), but attentional performance was not better [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992708/ [2] https://www.ncbi.nlm.nih.gov/pubmed/30451374 [3] https://www.ncbi.nlm.nih.gov/pubmed/27833051
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